Jan 23, 2014 · The RNHL domain of PF14239 proteins contains a RRXRR motif ... The length of the RNase H-like domain in different proteins ... DNA binding domain ( ...
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... proteins has been known as the 'RNase H fold'. RNases H bind to RNA/DNA hybrids in a sequence-nonspecific manner and degrade the RNA strand. Two groups of ...
Ribonuclease H is a family of non-sequence-specific endonuclease enzymes that catalyze the cleavage of RNA in an RNA/DNA substrate via a hydrolytic ...
Type 3 enzymes contain an N-terminal TATA-binding protein (TBP)-like domain that enhances their binding to the substrate, similar to the HBD in RNases H1 (Fig.
Nov 12, 2021 · Metal ions are known to serve as binding cofactors in DNA-protein interactions (24,42,43). To monitor substrate recognition by RNase H ...
Feb 25, 2009 · It is noted that a folding motif of RNases H, termed RNase H-fold, has been found in other proteins with nuclease or polynucleotidyl ...
Cas9 (Streptococcus pyogenes): The RuvC domain with RNase H fold is separated into three parts (I–III); BH, bridge helix domain; REC1/2, recognition domains ( ...
We speculate that the bound sulfate molecules mimic the binding of the phosphate backbone of the DNA. In RNase HI, a sulfate molecule was observed in the apo‐ ...
A similar fold and related active sites have since been found in RNase ... RNase H-like ... protein-nucleic-acid interactions remain the same as in the D132N mutant ...
Sep 14, 2017 · The RT and the RNase H are among the most ancient and abundant protein folds. RNases H may have evolved from ribozymes, related to viroids, ...